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Lyrica dosage, shapes and strengths

Drug Info Lyrica dosages typically start at 150 mg per day, which can be increased to a maximum of 450-600 mg per day

Lyrica (pregabalin) is a medicine usually prescribed for neuropathic pain and fibromyalgia. It can also be used as an adjunct treatment for partial seizures. The exact mechanism of action of Lyrica is not fully understood, but has been shown to reduce the release of neurotransmitters from pain in the spinal cord, similar to gabapentin . This differs from other painkillers in that it is specifically useful for nerve pain relief. Lyrica is believed to act through multiple pathways in the body. Lyricais usually taken in divided doses, two to three times a day, with or without food.

Lyrica shapes and strengths

  • Capsule: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg
  • Liquid solution: 20 mg per mL

Lyrica dosage for adults

Lyrica dosage will depend on the condition you are treating. For adults, the starting dose is 150 mg per day. The dosage is titrated to a desired dose with a maximum of 600 mg per day. However, patients with fibromyalgia usually have a maximum dosage of 450 mg per day.

Lyrica dosage chart for adults
Indication Initial dosage Standard dosage Maximum dosage
Diabetic peripheral neuropathy 50 mg orally 3 times a day 100 mg orally 3 times a day 600 mg / day
Neuropathic pain of the spinal cord 75 mg orally twice daily 150 mg orally twice daily 600 mg / day
Postherphetic neuralgia 150 mg / day orally divided 2-3 times a day 300 mg / day orally divided 2-3 times a day 600 mg / day
Partial-onset seizures (adjuvant treatment) 150 mg / day orally divided 2-3 times a day 150-600 mg per day orally divided 2-3 times a day 600 mg / day
Fibromyalgia 75 mg orally twice daily 150 mg orally twice daily 450 mg / day

The above dosages are for adults. Lyrica has been approved for adjuvant treatment for partial-onset seizures for those who are 1 month to 16 years of age. For this age group, the dosage is based on weight, which can be seen in the dosage section of children.

Lyrica dosage for diabetic peripheral neuropathy

Lyrica can be used to treat neuropathy that is caused by diabetes. Neuropathy is a condition that affects the peripheral nerves of the central nervous system. Symptoms of neuropathy include pain, numbness, weakness, or feeling of pins and needles.

The starting dose is usually 50 mg orally three times a day. In the first week, the dose can be increased to 100 mg orally three times a day. Doses greater than 300 mg per day are generally not effective and may increase the potential side effects of pregabalin or Lyrica. However, Lyrica can be taken up to 600 mg per day if necessary. When stopping Lyrica, gradually reduce the dose over a week.

Lyrica dosage for neuropathic spinal cord pain

When treating neuropathic pain associated with spinal cord injury, Lyrica can be started with 75 mg orally twice daily. In the first week, it can be increased to 150 mg orally twice daily. After another two to three weeks, it can be increased again to 300 mg orally twice daily, which is the maximum dose for this medicine. It should also be reduced gradually over the course of a week when stopping this medicine.

Lyrica dosage for postherphetic neuralgia

Lyrica can be used to treat postheretic neuralgia, which is the most common complication of herpes zoster, also known as cobreiro. It usually presents as a burning pain that can persist for weeks, months, or sometimes years after a herpes zoster outbreak.

The initial dosage for postherphetic neuralgia is 150 mg orally per day, divided into two or three doses. In the first week, it can be increased to 300 mg orally per day, also divided into two or three doses. After another two to four weeks, it can be increased to 600 mg orally per day, which is the maximum dose. It should be reduced gradually over the course of a week when stopping this medicine.

Lyrica dosage for fibromyalgia

Fibromyalgia is a condition characterized by pain, discomfort and fatigue. The exact cause of this condition is unknown, but is believed to be caused by signs of brain pain. Lyrica can help treat some of the pain caused by fibromyalgia. The starting dose is 75 mg orally twice daily. In the first week, it can be increased to 150 mg orally twice daily. The maximum dose of Lyrica for fibromyalgia is usually 450 mg per day, although up to 600 mg per day can be taken. However, doses above 450 mg per day have been shown to be ineffective in treating fibromyalgia with an increased risk of side effects. When interrupting Lyrica, it should be reduced gradually over the course of a week.

Lyrica dosage for partial seizures

Lyrica can also be used to treat partial seizures as adjuvant therapy, which means it is added to other medication regimens. For this indication, it can be used in patients one month of age or older with weight-based dosage.

For those who are 17 years or older, the initial dose is 150 mg orally per day, divided into two or three doses. Up to 600 mg per day can be taken orally, which is the maximum dosage for all ages. The effectiveness of treatments for seizures is dose-related, with more control of seizures at higher doses. However, higher doses have been shown to cause more side effects and potential risks.

Lyrica dosage for children

Lyrica is FDA approved for pediatrics as an adjunct treatment for partial seizures. For children from 1 month to 16 years of age, the dosage is determined by weight. There are two dosage categories for weight-based dosage. These categories are divided between those weighing less than 30 kg (66 pounds) and those who weigh 30 kg (66 pounds) or more.

Lyrica dosage by weight (ages 1 month to 16 years)
Weight Recommended dosage (tablet) Recommended dosage (liquid)
Less than 66 lbs (30 kg) 1.6-6.4 mg /pound (3.5-14 mg/kg) orally per day divided into two to three doses 20 mg per mL of oral solution: 0.08-0.32 mL / pound (0.175-0.7 mL / kg) per day divided into two to three doses *
Greater than or equal to 66 lbs (30 kg) 1.1-4.5 mg/pound (2.5-10 mg/kg) orally per day divided into two to three doses 20 mg per mL of oral solution: 0.06-0.23 mL / pound (0.125-0.5 mL / kg) per day divided into two to three doses

* For ages 1 month to 3 years weighing less than 30 kg (66 lbs), the dosage should be divided three times a day.

Lyrica dosage restrictions

Lyrica showed no significant differences in safety or efficacy in different age groups. Therefore, no dose adjustment is necessary for geriatric patients.

Lyrica can cause fetal damage if taken during pregnancy. The exact amount of damage is unclear because clinical studies are limited. In studies with animals related to reproduction, fetal structural abnormalities were observed. Pregnant mothers should always talk to their health professionals to assess the risks and benefits of taking Lyrica. It is recommended to enroll in the North American antiepileptic drug Pregnancy Registry (NAAED) if you are taking Lyrica during pregnancy. Breast-feeding while taking Lyrica is not recommended because it passes into breast milk. It is not known whether Lyrica can harm babies, but care must be taken. Ask a doctor before taking Lyrica during breastfeeding.

Lyrica reduced the dosage for those with reduced renal function. The dosage varies based on creatinine clearance (CrCl). There are no dosage adjustments required for those with reduced liver function. Fortunately, irregular liver enzymes do not affect the elimination of Lyrica.

Lyrica Renal Dosage Adjustments
Usual dose CrCl 30-60 mg /dL CrCl 15-29 mg/dL CrCl<15 mg/dL Hemodialysis
150 mg / day 75 mg / day divided into 2-3 doses 25-50 mg / day divided into 1-2 doses 25 mg once a day 25 mg once a day
300 mg / day 150 mg / day divided into 2-3 doses 75 mg / day divided into 1-2 doses 25-50 mg once a day 25-50 mg once a day
450 mg / day 225 mg / day divided into 2-3 doses 100-150 mg per day divided into 1-2 doses 50-75 mg once a day 50-75 mg once a day
600 mg / day 300 mg / day divided into 2-3 doses 150 mg / day divided into 1-2 doses 75 mg once a day 75 mg once a day

Lyrica dosage for pets

Lyrica can be given to dogs and cats to treat neuropathic pain and seizures. However, consult a veterinarian before giving this medicine to a pet. It can determine whether Lyrica is needed for a pet and what appropriate dose.

How to take Lyrica

Lyrica is usually taken orally in divided doses with or without food. It is usually given in two to three doses a day. This medicine should be taken as directed by a healthcare professional. The dose should be titrated over a few weeks until the desired dose is reached.

Lyrica dosage FAQs

How long does it take Lyrica to work?

Lyrica takes about 90 minutes to reach its maximum concentration in the body. The absorption rate of Lyrica decreases when it is taken with food. This extends the time required to achieve maximum effect to three hours. This does not mean that Lyrica should be taken on an empty stomach, because food has not been shown to reduce the effectiveness of Lyrica.

How long does Lyrica stay in your system?

The average half-life of Lyrica, which is the amount of time it takes half of the drug to leave the body, is about six hours in people with normal kidney function. Medications are usually eliminated after four to five half-lives, so it is estimated that Lyrica should be eliminated from the body after about 30 hours.

What happens if I miss a dose of Lyrica?

If a dose of Lyrica is forgotten, it should be taken as soon as it is remembered. However, if it is almost time for the next dose, the missed dose should be skipped and the next dose should be taken. Extra medication should not be taken to make up for a missed dose. If a dose is missed before bedtime, it should be taken the next morning. If the missed dose is not taken the next morning, the next dose should be taken at normal dosing time. Two doses should never be taken at the same time.

How do I stop taking Lyrica?

Reduce lyrica consumption for at least a week and do not stop taking it abruptly. Symptoms including insomnia, nausea, headache, anxiety, excessive sweating and diarrhea have been observed in patients who stopped taking Lyrica quickly. In addition, as with all medications that treat epilepsy, rapid discontinuation of this medication can potentially lead to increased frequency of seizures if Lyrica is being used to treat seizure disorders. Lyrica should not be discontinued without first consulting a doctor.

Although it is generally recommended not to interrupt Lyrica abruptly, there are certain exceptions. These include adverse events associated with hypersensitivity reactions (redness of the skin, blisters, hives, rash, difficulty breathing or panting) and angioedema (swelling of the throat, head or neck). Angioedema can be fatal and cause respiratory depression. If these symptoms appear, Lyrica should be discontinued immediately. However, it is important to consult a health professional when interrupting Lyrica.

What is the maximum dosage for Lyrica?

The maximum dosage of Lyrica is 600 mg per day, divided into multiple doses. However, doses higher than 450 mg per day were ineffective in patients with fibromyalgia.

What interacts with Lyrica?

The absorption rate of Lyrica is reduced when taken with food, but does not affect efficacy. If taken with food, it will take about three hours to achieve its full effect, while it would take 90 minutes without food. Therefore, Lyrica can be taken with or without food.

Lyrica is excreted predominantly in the urine in unchanged form. Less than 2% of Lyrica is metabolized before leaving the body. Because of this, Lyrica has no significant drug interaction. Specifically, there are no known drug interactions between Lyrica and other antiepileptic drugs that occur within the body.

Lyrica has the ability to reduce cognitive and motor function, so taking it with medications that also cause cognitive and motor impairment, such as oxycodone, lorazepam or ethanol, can cause additive effects. Be careful when combining Lyrica with medications that have similar side effects, especially opioids and CNS depressants. However, when taken together with these drugs, no significant adverse effects were observed in clinical trials. Since Lyrica can affect mood, patients who are already taking antidepressants should be evaluated before starting Lyrica.

Care should be taken in patients with heart failure because Lyrica may increase the risk of edema, which is fluid retention or swelling. Thiazolidinediones, a class of medications that treats diabetes, also increases the risk of edema. Taking Lyrica with thiazolidinedione can cause excessive fluid retention and possibly lead to heart failure. Consult a healthcare professional before taking these medications together. If necessary, doses can be adjusted so that both medications are safe for the patient.

Lyrica is excreted by the kidneys, so it can be affected by other medicines that affect the kidneys. Use lower doses in people with impaired kidney function.

What are some of the side effects of Lyrica?

Common side effects

  • Dry mouth
  • Confusion, difficulty concentrating
  • Constipation
  • Drowsiness or drowsiness

Serious side effects

  • Swelling of the throat, head or neck (angioedema)
  • Severe dizziness or drowsiness
  • Irregular heartbeat
  • Allergic reaction: itching or hives, swelling of the face or hands, swelling or tingling in the mouth or throat, chest tightening, difficulty breathing
  • Blisters, flaking, red rash
  • Blue lips, nails or skin, difficulty breathing, chest pain
  • Unusual bleeding, bruising, or weakness
  • Fever, chills, cough, sore throat, body aesters
  • Muscle pain, tenderness or weakness, general feeling of illness
  • Sudden or unusual change of mood or behavior, including extreme happiness or new depression or worsening
  • Risk of suicidal thoughts
  • Rapid weight gain, swelling in the hands, ankles or feet (edema)
  • Blurry or double vision
  • Decreased platelet count in the blood

Dizziness and drowsiness had the highest incidence compared to a placebo group in randomized clinical trials. If any serious side effects occur, consult a healthcare professional to make a plan to stop using Lyrica. Lyrica should be discontinued immediately if there is angioedema or hypersensitivity as they may be fatal.

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